An EPR Study of a Model System for the Initial Oxygen Activation Process Caused by Adriamycin-Iron System

DOI: 10.1246/cl.1987.933

Source and publish data:

Chemistry Letters p. 933 - 936 (1987)

Update date:2022-08-02

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Authors:

Tachibana, Masahiko

Tero-Kubota, Shozo

Iwaizumi, Masamoto

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Article abstract of DOI:10.1246/cl.1987.933

1,4-Dihydroxyanthraquinone, a model compound for Adriamycin, is reduced by Fe²⁺-ADP complex to generate semiquinone, while by Fe²⁺-phosphate complex to hydroquinone.The difference is explained in terms of the higher redox potential of the latter reducing agent.Similar reduction reactions were observed in the case of the drug.

Full text of DOI:10.1246/cl.1987.933

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