Identification of (1S)-Phosphoryloxy-(2R,4S)-dihydroxycyclohexane as a Potent Inhibitor of Inositol Monophosphatase

DOI: 10.1039/c39900000462

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 462 - 464 (1990)

Update date:2022-07-31

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Authors:

Baker, Raymond

Leeson, Paul D.

Liverton, Nigel J.

Kulagowski, Janusz J.

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Article abstract of DOI:10.1039/c39900000462

The 3,5,6-trisdeoxy derivative of myo-inositol 1-monophosphate, (1S)-phosphoryloxy-(2R,4S)-dihydroxycyclohexane <(-)-(1)>, derived from the parent substrate by a strategy of hydroxy deletion, has been synthesised and shown to be the most potent inhibitor of inositol monophosphatase yet identified.

Full text of DOI:10.1039/c39900000462

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