Derivatives of a Novel Cyclopeptolide. 2. Synthesis, Activity against Multidrug Resistance in CHO and KB Cells in Vitro, and Structure-Activity Relationships

DOI: 10.1021/jm00039a003

Source and publish data:

Journal of Medicinal Chemistry p. 1918 - 1928 (1994)

Update date:2022-09-26

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Authors:

Emmer, Gerhard

Grassberger, Maximilian A.

Schulz, Gerhard

Boesch, Danielle

Gaveriaux, Claire

Loor, Francis

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Article abstract of DOI:10.1021/jm00039a003

A series of derivatives of the novel cyclopeptolide 1 was prepared, and their ability to chemosensitize multi drug resistant CHO and KB cells in vitro was evaluated.In contrast to the parent compound, several of the derivatives were found to be highly act

Full text of DOI:10.1021/jm00039a003

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