Lipase mediated resolution of chiral (E)-vinylsilanes: An improved procedure for the production of (R)- and (S)-(E)-1-trialkylsilyl-1-buten-3-ol derivatives

Article abstract of DOI:10.1016/S0040-4039(00)79869-8

A crude enzymic extract of Pseudomonas AK in pentane catalyzes the transesterification of chiral (E)-vinylsilanes 1, resulting in the production of highly enantiomerically enriched (R)- and (S)-(E)-1-trialkylsilyl-1-buten-3-ol derivatives (S)-2 and (R)-3.