Bioorganic and Medicinal Chemistry Letters p. 1653 - 1656 (1996)
Update date:2022-08-02
Topics:
Dillon, Michael P.
Cai, Haiying
Maag, Hans
The synthesis and oral bioavailability of two potential prodrugs of Ganciclovir (1) based on the 'trimethyl lock' is described. The mono-3-(2'-Acetoxy-4'6'-dimethylphenyl)-3,3-dimethylpropanoic ester (2) showed a four-fold increase in oral bioavailability over the parent drug in rats.
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