Chemistry and structure-activity relationships of C-17 unsaturated 18-cycloalkyl and cycloalkyl analogues of enisoprost. Identification of a promising new antiulcer prostaglandin

DOI: 10.1021/jm00172a017

Source and publish data:

Journal of Medicinal Chemistry p. 2784 - 2793 (1990)

Update date:2022-08-02

Topics:

Authors:

Collins Collins

Gasiecki

Perkins Perkins

Gullikson

Bianchi Bianchi

Kramer Kramer

Yonan Yonan

Swenton Swenton

Jones Jones

Bauer Bauer

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Article abstract of DOI:10.1021/jm00172a017

A series of Δ¹⁷ unsaturated cycloalkyl and cycloalkenyl analogues of enisoprost was synthetized to investigate the effects of ω chain unsaturation on gastric antisecretory activity and diarrheogenic side effects. Of these, the 17E, 18-cyclopent

Full text of DOI:10.1021/jm00172a017

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