A facile and convenient synthetic method for fluorine-containing benz[c]acridines and dihydrobenz[c]acridines from N,N-dimethyl-1-naphthylamine

Article abstract of DOI:10.1055/s-1990-27114

Aromatic nucleophilic nitrogen-nitrogen exchange reaction of N,N-dimethyl-2,4-bis(trifluoroacetyl)-1-naphthylamine (1) with p-substituted anilines gives the corresponding N-aryl-2,4-bis(trifluoroacetyl)-1-naphthylamines 2 in high yield. Acid-catalyzed cyc