Development of a method for the synthesis of α-substituted α,β- unsaturated lactones based on stille-type Pd-catalyzed carbonylation of (Z)- ω-iodoalkenols. An efficient and selective synthesis of (+)-hamabiwalactone B

Article abstract of DOI:10.3987/com-99-s138

Pd-Catalyzed carbonylative lactonization of (Z)-ω-iodoalkenols can be applied to synthesize α/β-unsaturated lactones containing an alkenyl or alkynyl substituent in the α position, providing a generally superior alternative to recently developed methods involving Pd-catalyzed α- substitution of α-stannyl esters, as exemplified by a highly expeditious synthesis of (+)-hamabiwalactone B.