Synthesis of renin inhibitors possessing hydroxyethylene isostere residue from 3,4,6-tri-O-acetyl-D-glucal via lactone precursor

Article abstract of DOI:10.1016/S0040-4020(01)87085-X

Syntheses of precursors for renin inhibitors possessing hydroxyethylene isostere residue from 2,4,6-tri-O-acetyl-D-glucal via lactone precursor is described . This route makes it possible to synthesize analogues with various substituents at C-2 and C-5 of