Journal of Medicinal Chemistry p. 555 - 560 (1991)
Update date:2022-07-30
Topics:
Miwa, Tetsuo
Hitaka, Takenori
Akimoto, Hiroshi
Nomura, Hiroaki
New antifolates, characterized by a 6-5 fused ring system, a pyrrolo<2,3-d>pyrimidine ring, and a trimethylene bridge at position 5 (12a,b and 13a,b) were designed and efficiently synthesized.The synthetic method included (1) construction of the key inter
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