Novel Pyrrolopyrimidine Antifolates: Synthesis and Antitumor Activities

DOI: 10.1021/jm00106a012

Source and publish data:

Journal of Medicinal Chemistry p. 555 - 560 (1991)

Update date:2022-07-30

Topics:

Authors:

Miwa, Tetsuo

Hitaka, Takenori

Akimoto, Hiroshi

Nomura, Hiroaki

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Article abstract of DOI:10.1021/jm00106a012

New antifolates, characterized by a 6-5 fused ring system, a pyrrolo<2,3-d>pyrimidine ring, and a trimethylene bridge at position 5 (12a,b and 13a,b) were designed and efficiently synthesized.The synthetic method included (1) construction of the key inter

Full text of DOI:10.1021/jm00106a012

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