A Novel Application of "Benzotriazole" Methodology: Reactions of Polyhydroxylated bis-(benzotriazolyl) piperidines with Mono- and Bidentate Nucleophiles.

Article abstract of DOI:10.1016/S0040-4039(00)79279-3

A variety of 2,6-substituted trihydroxy piperidines 4 was synthesized with stereocontrol from the corresponding 2,6 bis-(Benzotriazolyl) trihydroxy piperidine 9, which in turn was prepared from 1,2-O-isopropylidene-D-glucofuranose 5 employing a simple, two step chemical manipulation.These products are potential glycosidase inhibitors and can be transformed to other useful chiral products.