A highly practical synthesis of natural PGE1,Δ2-trans-PGE1 and 2,2,3,3-tetradehydro-PGE1 via two-component coupling process using zinc-copper reagents

DOI: 10.1016/S0040-4039(00)97654-8

Source and publish data:

Tetrahedron Letters p. 4481 - 4484 (1990)

Update date:2022-08-02

Topics:

Authors:

Tsujiyama

Ono Ono

Yoshino Yoshino

Okamoto Okamoto

Sato Sato

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Article abstract of DOI:10.1016/S0040-4039(00)97654-8

A highly practical synthesis of natural PGE₁,Δ²-trans-PGE₁ and 2,2,3,3-tetradehydro-PGE₁ has been achieved in which the 1,4-addition reaction of the corresponding functionalized zinc-copper reagents to the enones 2 and/or 4 plays a key role.

Full text of DOI:10.1016/S0040-4039(00)97654-8

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