Molecules p. 4305 - 4317 (2011)
Update date:2022-07-31
Topics: Synthesis Mass spectrometry Chromatography Congeners Nuclear Magnetic Resonance (NMR) In vitro Testing In Vivo Testing Antitumor Activity Spectroscopy Experimental terms N1-(Coumarin-7-yl) amidrazones
Mustafa, Mohammad S.
El-Abadelah, Mustafa M.
Zihlif, Malek A.
Naffa, Randa G.
Mubarak, Mohammad S.
A series of new N1-(coumarin-7-yl)amidrazones incorporating N-piperazines and related congeners were synthesized by reacting the hydrazonoyl chloride derived from 7-amino-4-methylcoumarin with the appropriate piperazines. The chemical structures of the newly prepared compounds were supported by elemental analyses, 1H-NMR, 13C-NMR, and ESI-HRMS spectral data. The antitumor activity of the newly synthesized compounds was evaluated. Among all the compounds tested, 7-{2-[1-(4-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-yl) piperazin-1-yl)-2-oxopropylidene]hydrazinyl}-4-methyl-2Hchromen-2-one (3n) was the most potent against MCF-7 and K562 cells, with IC50 values of 20.2 and 9.3 iM, respectively.
View MoreSuzhou Jingye Medicine & Chemical Co., Ltd
website:http://www.jingyechem.cn
Contact:+86-512-66658588
Address:No. 88, Sanlian Street, Jinfeng Road, Suzhou New District, Jiangsu Province, P. R. China
Contact:+86-25-52346955
Address:199,JIANYE ROAD,NANJING,CHINA
Chuzhou Baiao Biologhy S&T Co., Ltd.
Contact:+86-25-83212599;+86-25-83212699 13705185959
Address:Room 905, Tianzheng International Platza, No.399, Zhongyang Road ,Nanjing, Jiangsu Province, China
Contact:0792-8228321
Address:10TH Floor No.121 binjiang Road Xunyang District
SHENZHEN PENGCHENG REDSTAR INDUSTRY CO.,LTD
Contact:+86-755-82412922
Address:Room 8066, East Block, Square City, Jiabin Road, Luohu District
Doi:10.1134/S1070428011030109
(2011)Doi:10.1021/ja00180a063
(1990)Doi:10.1021/acs.joc.9b03477
(2020)Doi:10.1016/j.tetlet.2010.06.058
(2010)Doi:10.1016/0008-6215(93)80029-E
(1993)Doi:10.1080/10426509808033732
(1998)