Synthesis of antitumor ansamycins. 2. A formal synthesis of (±)-macbecin I

Article abstract of DOI:10.1016/S0040-4039(00)97607-X

Convergent synthesis of (±)-2, a key intermediate in the Merck synthesis of macbecin I (1), incorporates the chelation-mediated coupling of a lithiated aryl subunit and the γ-hydroxy aldehyde equivalent 8 to establish a critical connective element of the