Bioorganic and Medicinal Chemistry Letters p. 4441 - 4446 (2015)
Update date:2022-08-02
Topics:
Choi, Jang-Sik
Hwang, Hae-Jun
Kim, Se-Won
Lee, Byung Il
Lee, Jaekyoo
Song, Ho-Juhn
Koh, Jong Sung
Kim, Jung-Ho
Lee, Phil Ho
A series of pyrazolylpyrimidine scaffold based Syk inhibitors were synthesized and evaluated for their biological activities and selectivity. Lead optimization efforts provided compounds with potent Syk inhibition in both enzymatic and TNF-α release assay.
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