Stereoselective synthesis of statin analogues

DOI: 10.1016/S0040-4039(00)97777-3

Source and publish data:

Tetrahedron Letters p. 4949 - 4952 (1990)

Update date:2022-08-04

Topics:

Authors:

Bernardi

Micheli Micheli

Potenza Potenza

Scolastico

Villa Villa

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Article abstract of DOI:10.1016/S0040-4039(00)97777-3

Statin analogues can be synthesized stereoselectively (diastereomeric ratios up to 4:1) starting from malic acid. The key step involves an unprecedented cis-selective allylation of an α-alkoxy N-acyliminium ion.

Full text of DOI:10.1016/S0040-4039(00)97777-3

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