The first synthesis of chiral phosphinocarboxylic acid ligands, trans-2-(diphenylphosphino) cycloalkanecarboxylic acids. The phosphine-palladium complexes catalyzed asymmetric allylic alkylation

Article abstract of DOI:10.1016/S0040-4039(00)97502-6

The first synthesized chiral phosphinocarboxylic acids were effective as ligand for the palledium-catalyzed asymmetric allylic alkylation of 3-acetoxy-1,3-diphenyl-1-propene and 2-cyclohexenyl acetate with soft carbanion from dimethyl malonate or triethyl phosphonoacetate and sodium hydride to give the alkylation products of up to 83% ee.