Organic and Biomolecular Chemistry p. 3154 - 3157 (2011)
Update date:2022-07-30
Topics:
Lee, Hsueh-Yun
Chang, Jang-Yang
Chang, Ling-Yin
Lai, Wen-Yang
Lai, Mei-Jung
Shih, Kuang-Hsing
Kuo, Ching-Chuan
Chang, Chi-Yen
Liou, Jing-Ping
In an attempt to mimic the 3,4,5-trimethoxyphenyl-Z-stilbene moiety of combretastatin A-4, a series of N-aryl-5,6,7-trimethoxyindoles were synthesized via copper-catalyzed Ullmann-type N-arylation through the corresponding 5,6,7-trimethoxyindole and aryl halides. These synthesized compounds demonstrated potent antiproliferative activity providing a novel skeleton for potent tubulin polymerization inhibitors.
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(2011)