Nucleosides and nucleotides. 97. Synthesis of new broad spectrum antineoplastic nucleosides, 2'-deoxy-2'-methylidenecytidine (DMDC) and its derivatives

DOI: 10.1021/jm00106a049

Source and publish data:

Journal of Medicinal Chemistry p. 812 - 819 (1991)

Update date:2022-08-03

Topics:

Authors:

Matsuda Matsuda

Takenuki

Tanaka Tanaka

Sasaki Sasaki

Ueda Ueda

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Article abstract of DOI:10.1021/jm00106a049

A new type of antineoplastic nucleoside, 2'-deoxy-2'-methylidenecytidine (DMDC) has been synthesized from the corresponding 2'-keto pyrimidine nucleosides 3 and 8 by the Wittig reaction. During the course of the reaction, we found that an intermediate bet

Full text of DOI:10.1021/jm00106a049

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Product name:[(2R,3S,3aR,9aR)-2-(4-Ethoxy-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ylmethyl]-triphenyl-phosphonium; bromide

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