Journal of Medicinal Chemistry p. 315 - 319 (1991)
Update date:2022-07-30
Topics: Derivatives Boron Melanoma
Tjarks, Werner
Gabel, Detlef
Boron-containing derivatives of 2-thiouracil and 2,4-dithiouracil and the corresponding 6-propyl compounds, containing a dihydroxyboryl group in the 5-position, have been prepared.These compounds accumulate in B16 melanoma in mice in concentrations up to 30 μg of boron per gram tissue.The uptake persists.The toxicity of both 2-thiouracil derivatives is low.These compounds are therefore good candidates for boron neutron-capture therapy of malignant melanoma.
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