Boron-Containing Thiouracil Derivatives for Neutron-Capture Therapy of Melanoma

Article abstract of DOI:10.1021/jm00105a049

Boron-containing derivatives of 2-thiouracil and 2,4-dithiouracil and the corresponding 6-propyl compounds, containing a dihydroxyboryl group in the 5-position, have been prepared.These compounds accumulate in B16 melanoma in mice in concentrations up to 30 μg of boron per gram tissue.The uptake persists.The toxicity of both 2-thiouracil derivatives is low.These compounds are therefore good candidates for boron neutron-capture therapy of malignant melanoma.