Chemical Communications p. 5166 - 5168 (2011)
Update date:2022-07-29
Topics:
West, Nicholas P.
Cergol, Katie M.
Xue, Millie
Randall, Elizabeth J.
Britton, Warwick J.
Payne, Richard J.
The first targeted inhibitors of an essential M. tuberculosis cell wall lipase, Rv3802c, are described. Lead compounds exhibited nanomolar inhibition of the enzyme, and encouraging antibacterial activity against M. tuberculosis in vitro, supporting Rv3802c as a novel TB drug target.
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(2011)Doi:10.1039/c1cc11211b
(2011)Doi:10.1002/cmdc.201100077
(2011)
