Synthesis and evaluation of DNA-targeted spatially separated bis(aniline mustards) as potential alkylating agents with enhanced DNA cross-linking capability

DOI: 10.1021/jm00105a038

Source and publish data:

Journal of Medicinal Chemistry p. 240 - 248 (1991)

Update date:2022-08-05

Topics:

Authors:

Gourdie Gourdie

Prakash Prakash

Wakelin Wakelin

Woodgate

Denny Denny

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Article abstract of DOI:10.1021/jm00105a038

DNA-targeted separated bis-mustards were synthesized by attaching aniline mono-mustards at the 4- and 9-positions of the DNA-intercalating ligand 9-aminoacridine-4-carboxamide, with the intention of improving the low cross-link to monoadduct ratio found w

Full text of DOI:10.1021/jm00105a038

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