Synthetic Communications p. 1977 - 1989 (2011)
Update date:2022-09-26
Topics:
Cherepakha, Artem
Kovtunenko, Vladimir O.
Tolmachev, Andrey
Lukin, Oleg
Nazarenko, Konstantin G.
o-Bromoarylsulfonylated amidines prepared either by acylation of amidine with o-bromoarylsulfonyl chloride or through the reaction of o-bromoarylsulfoamide with lactime ether underwent Cu(I)-catalyzed intramolecular cyclization to give 4H-1,2,4-benzothiadiazine-1,1-dioxides in good yield. By varying substituents on arylsulfonyl moieties, amidines, and lactime ethers, a small library of structurally diverse 4H-1,2,4- benzothiadiazine-1,1-dioxide derivatives was prepared.
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(1997)