Non-steroidal antiandrogens. Design of novel compounds based on an infrared study of the dominant conformation and hydrogen-bonding properties of a series of anilide antiandrogens

DOI: 10.1021/jm00105a067

Source and publish data:

Journal of Medicinal Chemistry p. 447 - 455 (1991)

Update date:2022-08-04

Topics:

Authors:

Morris Morris

Hughes Hughes

Glen Glen

Taylor Taylor

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Article abstract of DOI:10.1021/jm00105a067

Antiandrogenic activity is observed in anilides containing a tertiary hydroxyl group, and these compounds are used to define a pharmacophore in terms of their physicochemical properties. Infrared spectroscopy shows that these anilides exist in a single co

Full text of DOI:10.1021/jm00105a067

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