Tetrahedron Letters p. 6169 - 6172 (1993)
Update date:2022-07-30
Topics:
Diederich, Ann M.
Ryckman, David M.
A stereoselective synthesis of a hydroxyethylene dipeptide isostere for Phe-Gly, (4S, 5S)-4-hydroxy-5-amino-6-phenylhexanoic acid, is described.The use of dibenzyl protecting groups on ketoamine 5 accounts for the selectivity on reduction.Also, the dibenzyl group plays a role in directing the introduction of a third chiral center.
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(1988)Doi:10.1016/S0040-4039(00)82475-2
(1988)Doi:10.1002/adsc.200900069
(2009)Doi:10.1002/anie.200902942
(2009)Doi:10.1002/ejoc.200900735
(2009)Doi:10.1055/s-0029-1217995
(2009)
