Inhibition of human leukocyte elastase by functionalized N-aryl azetidin-2-ones: Substituent effects at C-3 and benzylic positions

DOI: 10.1016/0223-5234(96)88226-2

Source and publish data:

European Journal of Medicinal Chemistry p. 199 - 208 (1995)

Update date:2022-07-29

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Authors:

Vergely Vergely

Boggetto

Okochi Okochi

Golpayegani

Reboud-Ravaux

Kobaiter

Joyeau Joyeau

Wakselman

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Article abstract of DOI:10.1016/0223-5234(96)88226-2

A series of functionalized N-aryl azetidin-2-ones with a latent alkylating group was prepared by a flexible four-step synthesis, They met criteria expected for a suicide-type inactivation of human leukocyte elastase (HLE) and porcine pancreatic elastase (

Full text of DOI:10.1016/0223-5234(96)88226-2

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Product name:N-(4-hydroxymethylphenyl)-3,3-difluoroazetidin-2-one

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