Diastereoselectivity in the Addition of Grignard Reagents to Ketones Controlled by the 1,3-Dithiane 1-Oxide Asymmetric Building Block

Article abstract of DOI:10.1016/S0040-4020(01)80562-7

2-Acyl-1,3-dithiane 1-oxide undergo diastereoselective addition of Grignard reagents; the degree of selectivity observed is highly dependent upon the solvent and the halide counter-ion used; very high selectivities have been observed under certain reactio