Tetrahedron Letters p. 5717 - 5720 (1990)
Update date:2022-08-03
Topics: Strecker synthesis Asymmetric catalysis Organocatalysis Chiral Auxiliary Approach Chirality transfer Transition Metal-Catalyzed Reactions Enzymatic Resolution Chiral Pool Approach
Gmeiner
An efficient method for the synthesis of chiral β-amino acids starting from (S)-asparagine is shown. The key intermediate is an activated β-homoserine equivalent, which can be reacted with organocuprates to yield β-N,N-dibenzylamino nitrite derivatives. After deprotection the β-amino acids are obtained enantiomerically pure in high overall yield.
View MoreContact:86-379-63338609
Address:Jiudian Village,Deting Town,Song County,Luoyang
Zhonghao (dalian) Research and Design Institute of Chemical Industry Co., Ltd
Contact:+86 411 84674606
Address:201, Huangpu Road , Shahekou District, Dalian ,116023-China
Qida Chemical Co., Ltd.(expird)
Contact:+86-25-8776 0031
Address:3-2001 Jiaye Int'l Town, 158 Lushan Road,Nanjing, 210019, China
zhejiang huangyan wanfeng pharm chem co.ltd
Contact:+86-576- 84160728
Address:No. 5 Dazha Road, Economic,Development Zone(JiangKou), Zhejiang, China
Shanghai Demand Chemical Co., ltd,China
Contact:86-021-55237578/55239122
Address:Room 3H, No.578, Yingkou Road, Yangpu District, Shanghai, China
Doi:10.1039/b917304h
(2009)Doi:10.1016/j.bmc.2011.02.006
(2011)Doi:10.1039/c1cc10806a
(2011)Doi:10.1021/ic200113u
(2011)Doi:10.1016/j.bmc.2011.04.042
(2011)Doi:10.1016/j.cclet.2011.01.032
(2011)