Tetrahedron Letters p. 5717 - 5720 (1990)
Update date:2022-08-03
Topics: Strecker synthesis Asymmetric catalysis Organocatalysis Chiral Auxiliary Approach Chirality transfer Transition Metal-Catalyzed Reactions Enzymatic Resolution Chiral Pool Approach
Gmeiner
An efficient method for the synthesis of chiral β-amino acids starting from (S)-asparagine is shown. The key intermediate is an activated β-homoserine equivalent, which can be reacted with organocuprates to yield β-N,N-dibenzylamino nitrite derivatives. After deprotection the β-amino acids are obtained enantiomerically pure in high overall yield.
View MoreSichuan Highlight Fine Chemicals Co., Ltd.
Contact:+86-28-8525 1605
Address:A5-102 Airport base,388 West Airport Huang He Zhong Lu,2 Section
Zhangjiagang Golden Reach Fine Chemical Co.,LTD.
Contact:+86-512-6585 6968
Address:Changfu Road， Dongsha Chemical Industry Park, Zhangjiagang City, Jiangsu Province, China
Dongguan Albiya Energy Science and Technology Co.,Ltd
Contact:+86-769-22181286
Address:Huanan Industial Park, Dongguan,China
Anhui Asahikasei Chemical Co., Ltd
Contact:86-551-4259770
Address:No. 88 Linquan Road Hefei Anhui China
Shijiazhuang Frontierchem Co., Ltd.
Contact:+86-311-89271196
Address:4-4-202 No.15 Biandian Street,Shijiazhuang
Doi:10.1039/b917304h
(2009)Doi:10.1016/j.bmc.2011.02.006
(2011)Doi:10.1039/c1cc10806a
(2011)Doi:10.1021/ic200113u
(2011)Doi:10.1016/j.bmc.2011.04.042
(2011)Doi:10.1016/j.cclet.2011.01.032
(2011)
