Tetrahedron Letters p. 5717 - 5720 (1990)
Update date:2022-08-03
Topics: Strecker synthesis Asymmetric catalysis Organocatalysis Chiral Auxiliary Approach Chirality transfer Transition Metal-Catalyzed Reactions Enzymatic Resolution Chiral Pool Approach
Gmeiner
An efficient method for the synthesis of chiral β-amino acids starting from (S)-asparagine is shown. The key intermediate is an activated β-homoserine equivalent, which can be reacted with organocuprates to yield β-N,N-dibenzylamino nitrite derivatives. After deprotection the β-amino acids are obtained enantiomerically pure in high overall yield.
View MoreAnhui Eapearl Chemical Co., Ltd.
Contact:86-562-5858458
Address:358 South Huaihe Road
Nanjing Hemings New Material Tech Co.,Ltd.
Contact:+86-25-86606739
Address:NO.186 Jiangdong Mid Road,Nanjing China
Binzhou Holly Pharmaceutical Co.,Ltd.
Contact:74517
Address:No.15 Dapu Road,Huangpu District Shanghai,P.R.China
Contact:+44 (0)161 367 9441
Address:
Tianjin Dongchang Fine Chemical Industry Co., Ltd.
Contact:+86-22-29894595
Address:Economic Developing Zone, Ji County, Tianjin, China
Doi:10.1039/b917304h
(2009)Doi:10.1016/j.bmc.2011.02.006
(2011)Doi:10.1039/c1cc10806a
(2011)Doi:10.1021/ic200113u
(2011)Doi:10.1016/j.bmc.2011.04.042
(2011)Doi:10.1016/j.cclet.2011.01.032
(2011)
