Convergent synthesis and biological evaluation of 2-amino-4-(3′, 4′,5′-trimethoxyphenyl)-5-aryl thiazoles as microtubule targeting agents

Article abstract of DOI:10.1021/jm200392p

Combretastatin A-4, a potent tubulin polymerization inhibitor, caused us to synthesize a novel series of 2-amino-4-(3′,4′,5′- trimethoxyphenyl)-5-aryl thiazoles with the goal of evaluating the effects of substituents on the phenyl at the 5-position of the