Palladium-catalyzed coupling of haloalkynes with allyl acetate: A regio- and stereoselective synthesis of (Z)-β-haloenol acetates

Article abstract of DOI:10.1021/jo2005318

A Pd-catalyzed coupling of haloalkynes with allyl acetate has been reported, providing a convenient method for the stereoselective synthesis of (Z)-β-haloenol acetates in good yields. The synthetic utility of this method is demonstrated by the formation of functionalized enol acetates via the Suzuki-Miyaura or Sonogashira coupling of the resulting (Z)-β-haloenol acetate products.