144. Rogiolol Acetate: a Novel β-Chamigrene-Type Sesquiterpene Isolated from a Marine Sponge

Article abstract of DOI:10.1002/hlca.19900730606

The marine sponge Spongia zimocca SCHMIDT, 1862, collected in front of the torrent Il Rogiolo, south of Livorno, contains the sesquiterpene rogiolol acetate (=(+)-(2R,3S,6R,8R,9R)-2,8-dibromo-9-chloro-1,1,9-trimethyl-5-methylidenespiro<5.5>undec-3-yl acetate; (+)-3a), which represents the first chamigrane isolated from a sponge.Although compounds of this class are common in red seaweeds of the genus Laurencia, and our sponge actually contains 9-bromochamigrene and a variety of other metabolites of nearby growing Laurencia sp., (+)-3a is unique to our sponge.