Direct Fmoc-chemistry-based solid-phase synthesis of peptidyl thioesters

Article abstract of DOI:10.1021/jo200497j

Attachment of a growing peptide chain to a glycylaminomethyl resin via a thioglycinamide bond is compatible with Fmoc-chemistry solid-phase peptide synthesis. Subsequent S-alkylation of the thioamide gives a thioimide that, on treatment with aqueous trifl