A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners

DOI: 10.1021/jm00107a020

Source and publish data:

Journal of Medicinal Chemistry p. 1011 - 1018 (1991)

Update date:2022-07-30

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Authors:

Mylari Mylari

Beyer Beyer

Siegel Siegel

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Article abstract of DOI:10.1021/jm00107a020

Ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate (1, EBPC) is a potent and specific inhibitor of aldose reductase. It was >4000X more potent in its inhibition of rat lens aldose reductase than the closely related rat or pig kidney aldehyde reductas

Full text of DOI:10.1021/jm00107a020

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