Synthesis and Biological Evaluation of a Series of 1,1-Dichloro-2,2,3-triarylcyclopropanes as Pure Antiestrogens

DOI: 10.1021/jm00106a052

Source and publish data:

Journal of Medicinal Chemistry p. 842 - 851 (1991)

Update date:2022-07-29

Topics:

Authors:

Day, Billy W.

Magarian, Robert A.

Jain, Pramod T.

Pento, J. Thomas

Mousissian, Gorgin K.

Meyer, Karen L.

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Article abstract of DOI:10.1021/jm00106a052

A series of 1,1,-dichloro-2,2,3-triarylcyclopropanes (DTACs) was synthesized and evaluated as pure antiestrogens.Addition of 4-methoxy- or 4-(benzyloxy)phenyl Grignard reagents to p-methoxy, p-benzyloxy, or unsubstituted deoxybenzoins, followed by dehydra

Full text of DOI:10.1021/jm00106a052

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