Assignment of Stereochemistry in the Oligomycin/Rutamycin/Cytovaricin Family of Antibiotics. Asymmetric Synthesis of the Rutamycin Spiroketal Synthon

DOI: 10.1021/jo00313a011

Source and publish data:

Journal of Organic Chemistry p. 6260 - 6268 (1990)

Update date:2022-08-03

Topics:

Authors:

Evans, David A.

Rieger, Dale L.

Jones, Todd K.

Kaldor, Stephen W.

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Article abstract of DOI:10.1021/jo00313a011

The absolute stereochemistry of the rutamycin antibiotics 2a,b has been established through asymmetric synthesis of the known degradation product 4.One of the key steps in the assemblage process involves acylation of the metalated hydrazone 6 with the N-m

Full text of DOI:10.1021/jo00313a011

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