Biologically Active Taxol Analogues with Deleted A-Ring Side Chain Substituents and Variable C-2' Configurations

DOI: 10.1021/jm00107a042

Source and publish data:

Journal of Medicinal Chemistry p. 1176 - 1184 (1991)

Update date:2022-08-03

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Authors:

Swindell, Charles S.

Krauss, Nancy E.

Horwitz, Susan B.

Ringel, Israel

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Article abstract of DOI:10.1021/jm00107a042

Taxol (1), a potent inhibitor of cell replication, enhances the assembly of tubulin into stable microtubules and promotes the formation of microtubule bundles in cells.In addition to its unique mechanism of action, taxol exhibits unusual promise as an ant

Full text of DOI:10.1021/jm00107a042

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