Self-Reproduction of Chirality. Asymmetric Synthesis of β-Aryl-β-amino Acids from Enantiomerically Pure Dihydropyrimidinones

Article abstract of DOI:10.1021/jo00004a005

Enantiomerically pure dihydropyrimidinone 1 reacts with aryl iodides in the presence of catalytic amounts of Pd(OAc)2 and added phosphine to afford dihydropyrimidinone 4, in which a formal conjugate addition of the aryl group to the α,β-unsaturated system