Enantioselective Syntheses of Vinblastine, Leurosidine, Vincovaline, and 20'-epi-Vincovaline

DOI: 10.1021/jo00002a008

Source and publish data:

Journal of Organic Chemistry p. 513 - 528 (1991)

Update date:2022-08-03

Topics:

Authors:

Kuehne, Martin E.

Matson, Patricia A.

Bornmann, William G.

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Article abstract of DOI:10.1021/jo00002a008

The binary indole-indoline alkaloids vinblastine (1), leurosidine (13), 20'-epi-vincovaline (14a), and vincovaline (14b) were obtained by coupling of vindoline (3) to the tetracyclic intermediates 7a, 7b or 22a, 22b, followed by reduction and cyclization

Full text of DOI:10.1021/jo00002a008

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