OXIDATIVE DEBENZYLATION OF 4-METHOXY-α-METHYLBENZYL ESTERS

DOI: 10.1016/S0040-4039(00)97992-9

Source and publish data:

Tetrahedron Letters p. 5913 - 5916 (1990)

Update date:2022-08-04

Topics:

Authors:

Yoo, Sung-Eun

Kim, Hye Ryung

Yi, Kyu Yang

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Article abstract of DOI:10.1016/S0040-4039(00)97992-9

4-Methoxy-α-methylbenzyl alcohol was introduced as a new protecting group for carboxylic acids. 4-Methoxy-α-methyl benzyl esters obtained from the coupling of 4-methoxy-α-methylbenzyl alcohol and corresponding acids, were hydrolyzed in good yield by 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ).This process is compatible with several functional groups which are vulnerable to the reductive debenzylation reaction.

Full text of DOI:10.1016/S0040-4039(00)97992-9

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