Synthesis of (+)-5,6,7-trinor-4,8-inter-m-phenylene PGI2

DOI: 10.1016/S0040-4039(00)97657-3

Source and publish data:

Tetrahedron Letters p. 4493 - 4494 (1990)

Update date:2022-08-04

Topics:

Authors:

Nagase, Hiroshi

Matsumoto, Kazuhisa

Yoshiwara, Hideo

Tajima, Atsuko

Ohno, Kiyotaka

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Article abstract of DOI:10.1016/S0040-4039(00)97657-3

The titled compound, which is a stable and potent analog of prostacyclin, was synthesized from readily available 1,4-dibromocyclopentene via cyclopenta[b]benzofuran carboxylic acid 5.

Full text of DOI:10.1016/S0040-4039(00)97657-3

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Product name:4-[(1R,2R,3aS,8bS)-2-Hydroxy-1-((E)-(R)-3-hydroxy-oct-1-enyl)-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-5-yl]-butyric acid methyl ester

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