SYNTHESIS OF DERIVATIVES OF 4-ALKYLTHIOURACIL, CYTOSINE, PYRIDOPYRIMIDINE, AND PYRIMIDOPYRIMIDINE FROM THE N,S- AND N,N-ACETALS OF DIACETYLKETENE AND ISOCYANATES

Article abstract of DOI:10.1007/BF00961050

The action of alkyl and aryl isocyanates on the N,S-acetals of diacetylketene leads to the formation of 4-alkylthio-5-acetyl-1-alkyl(aryl)-6-methyl-1H-pyrimidin-2-ones (derivatives of 4-alkylthiouracils).The reaction of the synthesized thiouracils with am