A new synthesis of thiophosphoric acid esters with a C-S-P bond

Article abstract of DOI:10.1016/0040-4039(90)87018-U

Various S-substituted thiosuccinimides 1a-d and thiophthalimides 2a-d were found to react with trialkylphosphites according to a Michaelis-Arbuzov type mechanism. This provides an efficient way to prepare thiophosphoric acid esters, particularly thiophospholipids, with a C-S-P bond.