Fluorinated sugar analogues of potential anti-HIV-1 nucleosides

DOI: 10.1021/jm00109a017

Source and publish data:

Journal of Medicinal Chemistry p. 1640 - 1646 (1991)

Update date:2022-08-03

Topics:

Authors:

Huang Huang

Chen Chen

Wang Wang

Kim Kim

Warshaw Warshaw

Armstrong

Zhu Zhu

Chou Chou

Watanabe

Matulic-Adamic

Fox Fox

Polsky Polsky

Baron Baron

Gold Gold

Hardy Hardy

Zuckerman

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Article abstract of DOI:10.1021/jm00109a017

In order to obtain agents with therapeutic indices superior to those of AZT, FLT, or D4T, several analogues of anti-HIV-1 nucleosides were synthesized. These include 2',3'-dideoxy-2',3'-difluoro-5-methyluridine (13), its arabino analogue 19, arabino-5-met

Full text of DOI:10.1021/jm00109a017

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