Silylprotection in the solid-phase synthesis of N-linked neoglycopeptides. One-step deprotection of fully protected neoglycopeptides

Article abstract of DOI:10.1016/S0040-4039(00)73692-6

Silyl protection of the saccharide part in a building block for solid-phase synthesis of N-linked neoglycopeptides is described. Per-O-(trimethylsilylated) 1-amino-1-deoxy-D-glucitol 3 was reacted selectively with N(α)-Fmoc-Asp(Cl)-OPfp 1 and the resultin