SYNTHESIS OF 1,3,4-THIADIAZOLE DERIVATIVES BY THE REACTION OF THIOSEMICARBAZIDE OR ITS 1- OR 4-SUBSTITUTED DERIVATIVES WITH SOME 1-BROMO-2-ACYLACETYLENES

Article abstract of DOI:10.1007/BF00472199

The reaction of thiosemicarbazide, 4-methyl-, 4-phenyl-, or 1-phenylthiosemicarbazides with 1-bromo-2-benzoyl(thenoyl-2)acetylenes in acetonitrile or glacial acetic acid yielded 2-acylmethylene- and 2-acylmethyl-5-amino-1,3,4-thiadiazoles.Heating of the l