A Simple Asymmetric Synthesis of 2-Substituted Pyrrolidines from 3-Acylpropionic Acids

DOI: 10.1021/jo00007a011

Source and publish data:

Journal of Organic Chemistry p. 2294 - 2296 (1991)

Update date:2022-08-06

Topics:

Authors:

Meyers, A. I.

Burgess, Laurence E.

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Article abstract of DOI:10.1021/jo00007a011

The title compounds have been prepared from 3-acylpropionic acids 2 and (-)-R-phenylglycinol in a three-step sequence in >98percent enantiomeric excess.The R group in 2 ultimately becomes the 2-substituent in the chiral pyrrolidine.

Full text of DOI:10.1021/jo00007a011

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