New unnatural L-nucleoside enantiomers: From their stereospecific synthesis to their biological activities

Article abstract of DOI:10.1080/07328319708006190

Several purine and pyrimidine β-L-dideoxynucleosides were stereospecifically synthesized and their antiviral properties examined. Two of them, namely β-L-2',3'-dideoxyadenosine (β-L-ddA) and its 2',3'- didehydro derivative (β-L-d4A) were found to have significant anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HSV) activities in cell culture.

Full text of DOI:10.1080/07328319708006190

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Nucleosides and Nucleotides
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New Unnatural L-Nucleoside
Enantiomers:From Their
Stereospecific Synthesis to Their
Biological Activities
G. Gosselin a , V. Boudou a , J.-F. Griffon a , G. Pavia a , C. Pierra
a , J.-L. Imbach a , A.-M. Aubertin b , R. F. Schinazi c , A. Faraj d
& J.-P. Sommadossi d
a Laboratoire Chimie Bioorganique, UMR CNRS 5625 , Université
Montpellier II , 34095, Montpellier
b Université Louis Pasteur, INSERM U 74 , 67000, Strasbourg,
France
c Veteran Affairs Medical Center, Emory University, School of
Medicine , Decatur, GA-30033
d University of Alabama, Department of Pharmacology ,
Birmingham, AL-35294, USA
Published online: 16 Aug 2006.
To cite this article: G. Gosselin , V. Boudou , J.-F. Griffon , G. Pavia , C. Pierra , J.-L. Imbach ,
A.-M. Aubertin , R. F. Schinazi , A. Faraj & J.-P. Sommadossi (1997) New Unnatural L-Nucleoside
Enantiomers:From Their Stereospecific Synthesis to Their Biological Activities, Nucleosides and
Nucleotides, 16:7-9, 1389-1398, DOI: 10.1080/07328319708006190
To link to this article: http://dx.doi.org/10.1080/07328319708006190
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