Papain-catalyzed aldol reaction for the synthesis of trifluoromethyl carbinol derivatives

Article abstract of DOI:10.1016/j.molcatb.2016.05.014

Papain from Carica papaya demonstrated catalytic promiscuity was first discovered to catalyze the synthesis of trifluoromethyl carbinol derivatives via aldol reaction between α,α,α-trifluoromethyl ketones and aliphatic ketones in a mixed solvent of DMF an