Synthesis, Annealing Properties, 19F NMR Characterization, and Detection Limits of a Trifluorothymidine-Labeled Antisense Oligodeoxyribonucleotide 21 mer

DOI: 10.1021/jo00011a028

Source and publish data:

Journal of Organic Chemistry p. 3602 - 3608 (1991)

Update date:2022-08-05

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Authors:

Gmeiner, William H.

Pon, Richard T.

Lown, J. William

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Article abstract of DOI:10.1021/jo00011a028

The synthesis and characterization are described of trifluorothymidine groups incorporated into an antisense 21 mer designed to target gene sequences that encode serine proteases in T-lymphocytes. 1H NMR titration studies on 3',5'-O-TPDS-trifluorothymidin

Full text of DOI:10.1021/jo00011a028

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Product name:5'-O-(4,4'-dimethoxytrityl)-3'-O-(methyl phosphor-N,N-diisopropylamidite)-α,α,α-trifluorothymidine

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