Journal of Medicinal Chemistry p. 647 - 656 (1991)
Update date:2022-08-03
Topics:
Jarvi, Esa T.
McCarthy, James R.
Mehdi, Shujaath
Matthews, Donald P.
Edwards, Michael L.
et al.
The design and synthesis of (E)- and (Z)-5'-fluoro-4',5'-didehydro-5'-deoxyadenosine (6 and 13, respectively), a new class of mechanism-based inhibitors of S-adenosyl-L-homocysteine (SAH) hydrolase, is described.A number of analogues of 6 and 13 were synt
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